Mrs. Frisby, a widowed mouse with four small children, is faced with a terrible problem. She must move her family to their summer quarters immediately, or face almost certain death. But her youngest son, Timothy, lies ill with pneumonia and must not be moved. Fortunately, she encounters the rats of NIMH, an extraordinary breed of highly intelligent, laboratory-enhanced creatures, who come up with a brilliant solution to her dilemma. And Mrs. Frisby in turn renders them a great service. She overcomes her own fears to help them escape to a civilization they built away from a world of dangers.